Peer-reviewed discovery platform and data in PNAS show that single transcription factor modulation reverses aging-associated gene expression and restores healthy cellular and tissue function in models ...

Life begins with a tiny orchestra of stem cells, setting the stage for the body’s grand symphony of development. As the performance unfolds, a dynamic interplay of factors takes center stage, ...

New library of 400 immune-related factors and screening platform can find precise recipes for reprogramming accessible cells ...

Jonas Salk quietly built the polio vaccine through rigorous, methodical work in Pittsburgh: treating patients, refining data, conducting massive trials, before unveiling results that altered the ...

GC Therapeutics, Inc. (GCTx), a biotechnology company created to scale and unlock the next generation of cell therapy-based medicines through its TFome™ cellular programming platform, today announced ...

Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells. Scientists ...

Cancer cells are tricky foes. Our body’s immune system is normally on the lookout for signs of tumor cells. If any are detected, it launches killer T cells—a type of immune cell—to seek and destroy ...

A new CRISPR interference (CRISPRi) model explores how the pioneer transcription factor FOXA controls human endoderm differentiation during liver development, and how the pioneer transcription factor ...

Transcription factors are the most powerful genes in our body. They are master regulators and have been implicated in our biggest diseases, even aging itself. Yet, many in the pharmaceutical industry ...